Jan 21, · “Patients with [triple-negative breast cancer] who received carboplatin as part of their neoadjuvant chemotherapy regimen were almost half as likely to have had disease relapse at 3 years after starting treatment compared with those who did not receive carboplatin, and it was those patients who had a pCR who were least likely to have disease relapse.”. The Adjuvant Platinum and Taxane in Triple-Negative Breast Cancer (PATTERN) trial investigated the combination of paclitaxel and carboplatin (PCb) in TNBC vs the standard-of-care anthracycline plus.
Role of Carboplatin in the Treatment of Triple Negative Early- Stage Breast Cancer Triple negative breast cancer (TNBC) is more prevalent in younger patients and those carrying BRCA mutations. Although the incidence of breast cancer in general has dropped during the last years, TNBC has shown a relative didlo.xyz by: 5. Jan 21, · The researchers pointed out that women diagnosed with triple-negative breast cancer without a BRCA1/2 mutation may benefit from the addition of carboplatin to neoadjuvant chemotherapy, while women with a BRCA1 or BRCA2 mutation may be able to have a less intense neoadjuvant chemotherapy regimen, but more research is needed to figure out the .
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial Germline mutations in BRCA1/2 predispose individuals to breast cancer (termed germline-mutated BRCA1/2 breast cancer, gBRCA-BC) by impairing homologous recombination (HR) and causing genomic didlo.xyz by: Mar 05, · Carboplatin Intensified Chemotherapy for TRIple NEgative Breast Cancer (CITRINE) (CITRINE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Sep 28, · The PATTERN (adjuvant Platinum and Taxane in Triple-Negation Breast Cancer), a phase III, multicenter, randomized, open-label clinical trial, examined whether adjunctive therapy with paclitaxel (PCb) and carboplatin was superior to a standard regimen of an anthracycline and docetaxel on survival in women with TNBC. Abstract Purpose: One third of patients with triple-negative breast cancer (TNBC) achieve pathologic complete response (pCR) with standard neoadjuvant chemotherapy (NACT). CALGB (Alliance), a 2 × 2 factorial, open-label, randomized phase II trial, evaluated the impact of adding carboplatin and/or didlo.xyz by: